Hypoxic Tolerance Enhanced By •Hydroxybutyrate-Glucagon in the Mouse
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چکیده
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منابع مشابه
Glucagon stimulates ketone utilization by rat brain slices.
Glucagon has been shown previously to increase further the enhanced tolerance for hypoxia observed in mice with elevated blood ketones. Glucagon is also known to increase blood glucose and to alter directly the metabolism of some (liver) cells. Both the increase in blood glucose and altered cellular metabolism could contribute to the increase in tolerance for hypoxia observed in mice given gluc...
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1,3-Butanediol is an ethanol dimer that induces systemic ketosis. It has previously been shown to increase hypoxic survival time and reduce neurologic deficit in several experimental preparations. The aim of this study was to determine if the mechanism of 1,3-butanediol-induced cerebral protection was elevation of blood ketone levels, blood glucagon levels, or both. Blood beta-hydroxybutyrate l...
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Introduction: Pro-inflammatory chemokines and cytokines such as MCP-1 and IL6 can activate microglial cells that has found in some neuro-inflammatory disorders. Hypoxia activates cerebral endothelial cells to release these pro-inflammatory mediators. We aimed to investigate the anti-hypoxic effects of different doses of some GABAergic agents. Materials and Methods: We randomly divid...
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A standard murine model was used to determine whether acute pretreatment exposures to hypoxia could alter ultimate hypoxic survival time. Adult male albino mice (Mus musculus) weighing 25-30 g were subjected to three pretreatment hypoxic exposures (4.5% O2, balance N2) of increasing duration (90, 120, and 150 seconds) with 300 seconds of normoxia between each pretreatment exposure and before te...
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تاریخ انتشار 2005