Review of AZT multicenter trial data
نویسنده
چکیده
The approval of AZT as a treatment for AIDS was based on the results of a single multicenter placebo controlled trial, the results of which were reported in the New England Journal of Medicine (NEMJ) of July 23, 1987. The most important efficacy parameter claimed for AZT was a reduction in mortality in AIDS and advanced ARC patients who received the drug compared to the patients receiving placebo. Additional efficacy parameters that purported to show benefits of AZT included a reduction in the occurrence of opportunistic infections (OIs), and increases in the numbers of T4 lymphocytes.
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تاریخ انتشار 2008