Hormone-sensitive lipase-independent adipocyte lipolysis during -adrenergic stimulation, fasting, and dietary fat loading
نویسندگان
چکیده
Divisions of Medical Genetics and Gastroenterology, Research Centre, Hôpital Ste.-Justine, Montreal, Quebec H3T 1C5; Division de Kinésiologie, Département de Médecine Sociale et Préventive, Université Laval, and Centre de Recherche de l’Hôpital Laval and Centre de Recherche sur le Métabolisme Énergétique de l’Université Laval, Département d’Anatomie et de Physiologie, Faculté de Médecine, Université Laval, Quebec, Canada G1K 7P4
منابع مشابه
Hormone-sensitive lipase-independent adipocyte lipolysis during beta-adrenergic stimulation, fasting, and dietary fat loading.
In white adipose tissue, lipolysis can occur by hormone-sensitive lipase (HSL)-dependent or HSL-independent pathways. To study HSL-independent lipolysis, we placed HSL-deficient mice in conditions of increased fatty acid flux: beta-adrenergic stimulation, fasting, and dietary fat loading. Intraperitoneal administration of the beta(3)-adrenergic agonist CL-316243 caused a greater increase in non...
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The mobilization of fat stored in adipose tissue is mediated by hormone-sensitive lipase (HSL) and the recently characterized adipose triglyceride lipase (ATGL), yet their relative importance in lipolysis is unknown. We show that a novel potent inhibitor of HSL does not inhibit other lipases. The compound counteracted catecholamine-stimulated lipolysis in mouse adipocytes and had no effect on r...
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تاریخ انتشار 2004