Orientia tsutsugamushi inhibits apoptosis of macrophages by retarding intracellular calcium release.
نویسندگان
چکیده
Orientia tsutsugamushi shows both pro- and antiapoptotic activities in infected vertebrate cells. Apoptosis of THP-1 cells induced by beauvericin was inhibited by O. tsutsugamushi infection. Beauvericin-induced calcium redistribution was significantly reduced and retarded in cells infected with O. tsutsugamushi. Antiapoptotic activities of O. tsutsugamushi in infected cells are most probably due to inhibition of the increase in the cytosolic calcium concentration.
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عنوان ژورنال:
- Infection and immunity
دوره 70 8 شماره
صفحات -
تاریخ انتشار 2002