Glycosylated Notch and Cancer
نویسندگان
چکیده
Glycosylation is one of the key components influencing several signaling pathways implicated in cell survival and growth. The Notch signaling pathway plays a pivotal role in numerous cell fate specifications during metazoan development. Both Notch and its ligands are repeatedly glycosylated by the addition of sugar moieties, such as O-fucose, O-glucose, or O-xylose, to bring about structural and functional changes. Disruption to glycosylation processes of Notch proteins result in developmental disorders and disease, including cancer. This review summarizes the importance and recent updates on the role of glycosylated Notch proteins in tumorigenesis and tumor metastasis.
منابع مشابه
Characterization of the mechanisms underlying the crosstalk between galectins and notch in gastric cancer
Background Gastric cancer is the fourth most common cancer and the second leading cause of cancer-related deaths worldwide. Galectins form a family of b-galactosides binding proteins that recognize a variety of glycan-containing proteins at the cell surface and are overexpressed in various tumors, including gastric cancer. Galectins overexpression as well as changes in their subcellular distrib...
متن کاملThe notch gene product is a glycoprotein expressed on the cell surface of both epidermal and neuronal precursor cells during Drosophila development
The Notch locus of Drosophila melanogaster is one of a small number of zygotically acting "neurogenic" genes involved in the correct segregation of neural from epidermal lineages during embryogenesis as well as in other postembryonic developmental events. We have generated antibody probes against three regions of the Notch protein to study the expression of Notch and begin a biochemical charact...
متن کاملInfluence of Notch Depth-to-Width Ratios on J-Integral and Critical Failure Load of Single-Edge Notched Tensile Aluminium 8011 Alloy Specimens
In this paper, the influence of notch depth-to-width ratios on J-integral and critical load of Aluminium 8011 alloy specimens with U-notch under Mode I loading are studied. Using experiments, for a set of specimens having different notch depth–to–width ratios, J-integral was found and the same was verified using analytical methods. Further, using the results obtained from the experiments, failu...
متن کاملHeterologous Immunization, a Way out of the Problem of Monoclonal Antibody Production against Carcinoma Antigen 125
Background: Monoclonal antibodies (mAbs) are essential tools for many molecular im-munology investigations, epitope mapping and molecular modelling, clinical laboratory di-agnostic tests and immunotherapy. Humoral immune response of immunized animals largely depends on the nature of antigen and the immunization technique. Polysaccharides and heavily-glycosylated proteins are very elusive target...
متن کامل[Frontiers in Bioscience 12, 4370-4383, May 1, 2007] 4370 Notch signaling and its role in breast cancer
1. Abstract 2. Introduction 3. Notch signaling pathway 3.1. Notch receptors and ligands 3.2. Notch signaling activation 3.3. Notch signaling targets 4. Notch signaling in tumorigenesis 4.1. Cell proliferation 4.2. Cell survival (apoptosis evasion) 4.3. Angiogenesis 4.4. Cell invasion and metastasis 4.5. Notch and viral oncogenes 4.5.1. EBV viral protein EBNA2 and Notch 4.5.2. HPV viral protein ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Frontiers in oncology
دوره 6 شماره
صفحات -
تاریخ انتشار 2016