Mode of action and In Vitro susceptibility of mastitis pathogens to macedocin ST91KM and preparation of a teat seal containing the bacteriocin

Mastitis Pathogens Containing This Bacteriocin for Inhibition of Evaluation of Lacticin 3147 and a Teat Seal

Relationship between in vitro susceptibility of bovine subclinical mastitis isolates and bacteriological outcome of intramammary treatment with cefquinome

The objective of the present study was to determine whether there was an association between the in vitro antimicrobial susceptibility test results of subclinical mastitis pathogens and bacteriological outcomes of intramammary treatments using cefquinome. A total of 110 intramammary pathogens from 51 cows were assessed in this study. Most intramammary infections were due to coagulase-negative s...

Efficacy of a teat dip containing the bacteriocin lacticin 3147 to eliminate Gram-positive pathogens associated with bovine mastitis.

On most dairy farms teat dips are applied to the teats of cows either before or after milking in order to prevent pathogens from gaining access to the mammary gland via the teat canal. In the present experiments, a natural teat dip was developed using a fermentate containing the live bacterium Lactococcus lactis DPC 3251. This bacterium produces lacticin 3147, a two-component lantibiotic which ...

Update on the development of a novel dry cow therapy using a bismuth-based intramammary teat seal in combination with the bacteriocin lacticin 3147

: Public concerns over the widespread prophylactic use of antibiotics have led to a search for alternatives to dry cow therapy for the prevention of intramammary infections. A popular alternative is to infuse a teat seal at drying-off. The teat seal is a viscous non-antibiotic formulation and when it is infused into the teat canal and the teat sinus it forms an internal seal that provides a phy...

The Use of a Bismuth-based Teat Seal and the Bacteriocin Lacticin 3147 to Prevent Dry Period Mastitis in Dairy Cows

Mastitis in dry cows has traditionally been controlled with long-acting intramammary antibiotic formulations. However, the widespread use of antibiotics, particularly for prophylactic application, is likely to be restricted in the future. As a consequence, there is now a growing requirement for effective alternatives to prevent mastitis. A bismuth-based, intramammary teat seal has recently been...