Aspirin intake suppresses MMC-induced genotoxicity in mice.
نویسندگان
چکیده
The genotoxicity induced by mitomycin C (MMC) was found to be decreased by aspirin on alkaline single cell gel electrophoresis (SCG) assay in multiple organs of mice. Aspirin at doses of 0.5, 5 and 50 mg/kg and MMC at 2 mg/kg were administered and then liver, lung, kidney, spleen, colon and bone marrow were sampled after 3 h. Significant protective effects of aspirin against MMC-induced genotoxicity was observed in all but the bone marrow, where no change was evident. The results suggest that the radical scavenging ability of aspirin prevents danage by MMC-induced reactive oxygen species (ROS) in multiple organs.
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عنوان ژورنال:
- Asian Pacific journal of cancer prevention : APJCP
دوره 9 2 شماره
صفحات -
تاریخ انتشار 2008