Combination of Local Transcatheter Arterial Chemoembolization and Systemic Anti- ngiogenic Therapy for A Unresectable Hepatocellular Carcinoma

Combination of local transcatheter arterial chemoembolization and systemic anti-angiogenic therapy for unresectable hepatocellular carcinoma.

The pathophysiologic complexity of hepatocellular carcinoma (HCC) and underlying hepatic cirrhosis, make optimal treatment choice a clinical challenge. The radical change in the treatment algorithm of patients with advanced unresectable HCC over the past 7 years, with the introduction of anti-angiogenic agents in patients with only preserved liver function reflect this challenge. Even though da...

Balloon-occluded percutaneous radio-frequency thermal ablation (RFA) plus transcatheter arterial chemoembolization (TACE): a new combined single- step therapy for treatment of unresectable hepatocellular carcinoma

Regional Transcatheter Therapy of Hepatic Neoplasms.

BACKGROUND: Surgical resection of hepatocellular carcinomas and metastases to the liver cannot always be performed, and systemic therapies for these entities are of limited value. The techniques of chemoembolization and hepatic artery infusion have been used for patients who are not candidates for surgery. METHODS: Chemoembolization uses percutaneous intra-arterial infusion of chemotherapeutic ...

Transcatheter arterial chemoembolization combined with percutaneous injection of ethanol-lipiodol mixture for treatment of hepatocellular carcinoma: a non-randomized controlled study of 122 cases

The aim is to evaluate effects and safety of the combination of transcather arterial chemoembolization (TACE) and percutaneous ethanol-lipiodol injection (PELI) for the treatment of unresectable hepatocellular carcinoma (HCC). A total of 122 patients (104 men and 18 women; mean age: 52 years old) with histopathologically proven HCC were consecutively enrolled for either the combination of TACE ...

Transcatheter arterial chemoembolization therapy for hepatocellular carcinoma using polylactic acid microspheres containing aclarubicin hydrochloride.

Transcatheter arterial chemoembolization therapy using polylactic acid microspheres containing aclarubicin hydrochloride (ACR) was performed in 62 patients with primary hepatocellular carcinoma. These microspheres were about 200 microns in diameter and contained 10% (w/w) aclarubicin. A single dose of polylactic acid microspheres containing ACR (50-100 mg of ACR) was administered 1 to 8 times w...