A Microfluidic Affinity Aptasensor

نویسندگان

  • T. H. Nguyen
  • R. Pei
  • M. Stojanovic
  • D. Landry
  • Q. Lin
چکیده

We present a prototype biosensor suitable for selective detection of analytes and controlled release of metabolic drug molecules. The device consists of microfabricated PDMS channels on glass with two microchambers (sensing and delivery) filled with ribonucleic acid aptamer responsive media. Using adenosine monophosphate (AMP) as an analyte and drug molecule, we demonstrate detection of trace amounts of AMP as well as controlled delivery of AMP by thermal activation. The system is viable and regeneratable in aqueous medium, providing long-term functionality on a biocompatible platform.

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تاریخ انتشار 2007