CREB, ATF, and AP-1 Transcription Factors Regulate IFN- Secretion by Human T Cells in Response to Mycobacterial Antigen
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CREB, ATF, and AP-1 transcription factors regulate IFN-gamma secretion by human T cells in response to mycobacterial antigen.
IFN-gamma production by T cells is pivotal for defense against many pathogens, and the proximal promoter of IFN-gamma, -73 to -48 bp upstream of the transcription start site, is essential for its expression. However, transcriptional regulation mechanisms through this promoter in primary human cells remain unclear. We studied the effects of cAMP response element binding protein/activating transc...
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تاریخ انتشار 2008