Honokiol and magnolol are the known bioactive constituents in the stem barks of Magnolia obovata and M. officinalis. Honokiol inhibits angiogenesis in vitro and tumor growth in vivo, lipid peroxidation in rat heart mitochondria, and arrhythmia

نویسندگان

  • Kwang - Hyun PARK
  • Seon - Young KIM
  • Rukhsana GUL
  • Byung - Ju KIM
  • Kyu Yun JANG
  • Hun - Taeg CHUNG
  • Dong - Hwan SOHN
چکیده

that is widely used in treatment of a broad spectrum of cancers. However, Dox exhibits serious side-effects such as manifestation of arterial and ventricular arrhythmia and development of cumulative dose-dependent cardiomyopathy. These Dox-induced cardiotoxicities are known to be caused mainly by ROS generation, resulting in elevation of intracellular Ca concentration ([Ca ]i) through release from sarcoplasmic reticulum. Although the cardiotoxicity of Dox is well recognized, preventive drugs have not been discovered. Various parts of plants have been used as a traditional medicine in Chinese, Korean, and Japanese for the treatment of various diseases. Magnolia officinalis REHD et WILS. (Horpu in Chinese) has been known to treat cold-stroke, cold damage, headache, and blood impediment. Honokiol and magnolol are the known bioactive constituents in the stem barks of Magnolia obovata and M. officinalis. Honokiol inhibits angiogenesis in vitro and tumor growth in vivo, lipid peroxidation in rat heart mitochondria, and arrhythmia in coronary ligated rats. Magnolol is also reported to reduce myocardial ischemia/reperfusion injury in rat via the inhibition of neutrophils migration. These bioactive small molecules are isolated from stem bark and/or root. However, none of the study has reported the presence of bioactive substances in Magnolia seed. In an effort for the reduction of Dox-induced cardiotoxicity, we evaluated ethanol extract of Magnolia seed. Three fatty acids were identified and effectively reduced Doxinduced cardiotoxicity in in vitro and in vivo. MATERIALS AND METHODS

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تاریخ انتشار 2008