Novel epothilone lactones by an unusual diversion of the Grubbs' metathesis reaction.
نویسندگان
چکیده
An unusual reaction with Grubbs' catalyst during the synthesis of bridged epothilones yielded five-membered internal lactones instead of the expected metathesis products. Three of the lactones have activities comparable to epothilone D.
منابع مشابه
Synthesis by Ring-Closing Metathesis and Cytotoxic Evaluation of Novel Thienylmacrolactones
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عنوان ژورنال:
- Chemical communications
دوره 46 12 شماره
صفحات -
تاریخ انتشار 2010