New behavioral mutant rat ( clx ) controlled by a sex - lin exhibiting circling behavior ked recessive gene

A male rat showing intermittent circling behayior was discovered among the Jcl:Wistar rats in our laboratories, and among its backcross offspring individuals howing the same behavior were found. The abnormaLities in these animals were characterized by intermittent circling behavior (walking andlor running in circles) and head tossing with the neck twisted. No abnormalities were obseryed in fenility, delivery or pup morta]ity. The results of mating experiments indicated that the circling behavior phenotype is controlled by a single sexlinked recessive gene, and the mutant was named ''circling behayior linked to X-chromosbme (gene symbol: cL:)." This circ]ing behavior mutant is considered to be different from the previously reported mutants, the behavior in al] of which has been found to be autosomally inherited. Sib-mating is continuing to prodllce an inbred strain with this newly discovered circling behavior mutant gene.