Human Cancer Biology Novel Tumor Subgroups of Urothelial Carcinoma of the Bladder Defined by Integrated Genomic Analysis
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چکیده
Purpose: There is a need for improved subclassification of urothelial carcinoma (UC) at diagnosis. A major aim of this study was to search for novel genomic subgroups. Experimental design:We assessed 160 tumors for genome-wide copy number alterations andmutation in genes implicated inUC. These comprised all tumor grades and stages and included 49 high-grade stage T1
منابع مشابه
Dysregulated Expression of Long Intergenic Non-coding RNAs (LincRNAs) in Urothelial Bladder Carcinoma
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Advanced urothelial carcinoma (UC) is a devastating illness with limited effective chemotherapy options for patients with metastatic disease. Molecularly targeted therapy has demonstrated substantial activity in many malignancies, including non–small-cell lung cancer (NSCLC), melanoma, breast cancer, colorectal cancer, and others. Over the past several years, the biology of UC has been better d...
متن کاملNovel tumor subgroups of urothelial carcinoma of the bladder defined by integrated genomic analysis.
PURPOSE There is a need for improved subclassification of urothelial carcinoma (UC) at diagnosis. A major aim of this study was to search for novel genomic subgroups. EXPERIMENTAL DESIGN We assessed 160 tumors for genome-wide copy number alterations and mutation in genes implicated in UC. These comprised all tumor grades and stages and included 49 high-grade stage T1 (T1G3) tumors. RESULTS ...
متن کاملگزارش یک مورد سرطان اوروتلیال پلاسماسیتوئید مثانه
Bladder cancer most commonly exists as an epithelial tumor in which around 90% of cases are transitional cell carcinoma (TCC) with a papillary appearance. The world health organization (WHO) classification defines new histological and molecular variants of urothelial carcinoma in 2004. One of them is plasmacytoid urothelial carcinoma (PUC). Less than 100 cases have been reported in the literatu...
متن کاملHigh-Grade Urothelial Carcinoma of Bladder Transforming to Micropapillary Variant on Follow-Up
Micropapillary variant of urothelial carcinoma (UC) of the bladder is an aggressive tumour, comprising 0.6-6% of all UC. It generally presents with high-grade and stage, and has been reported as having a worse prognosis when compared to traditional UC. We report the case of a 58-year-old man who presented with macroscopic haematuria. The patient was diagnosed with high-grade urothelial carcinom...
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تاریخ انتشار 2012