Phosphotransferase activities of kidney glucose 6-phosphatase.

Kidney glucose 6-phosphatase has been shown to catalyze inorganic pyrophosphatase and inorganic pyrophosphate-, cytidine diphosphate-, cytidine triphosphate-, and mannose 6-phosphate-glucose phosphotransferase reactions. The catalytic properties of phosphohydrolase and phosphotransferase activities of the kidney enzyme were found to be very similar to those of corresponding hepatic activities (11, 15). Formation and hydrolysis of glucose 6-phosphate by phosphotransferase and phosphohydrolase activities, respectively, of this enzyme are postulated to play a role in the transport of glucose across the kidney tubular cell of the diabetic animal.