Large serrated polyps: molecular and familial links to a serrated neoplasia predisposition
نویسندگان
چکیده
Background The serrated pathway to colorectal cancer is associated with a CpG-island methylator-phenotype (CIMP) and is distinct of the classical adenoma-to-carcinoma sequence. There is increasing evidence that a subset of hyperplastic polyps (HPs) serves as intermediates in an oncogenic sequence resulting in a CIMP colorectal cancer. This study analyzes molecular changes in large HPs to define their potential relationship to the serrated polyp pathway and links them to a predisposition to colorectal cancer.
منابع مشابه
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عنوان ژورنال:
دوره 8 شماره
صفحات -
تاریخ انتشار 2010