A versatile assay for monitoring in vivo-like transendothelial migration of neutrophils.
نویسندگان
چکیده
Spatiotemporal analysis of the inflammatory response has been limited by the difficulties of in vivo imaging and reconstitution of inflammation in vitro. Here, we present a novel method for establishing in vivo-like inflammatory models in a microfluidic device and quantitatively measuring the three-dimensional transmigration of neutrophils during the inflammatory process. This enabled us to concurrently characterize transendothelial migration behaviors of neutrophils under the influence of various inflammatory stimuli.
منابع مشابه
Recapitulation of in vivo-like neutrophil transendothelial migration using a microfluidic platform.
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عنوان ژورنال:
- Lab on a chip
دوره 12 20 شماره
صفحات -
تاریخ انتشار 2012