b-Adrenoceptors in vascular capacitance responses to unloading of carotid baroreceptors in anesthetized dogs

Karim, F., and S. M. Poucher. b-Adrenoceptors in vascular capacitance responses to unloading of carotid baroreceptors in anesthetized dogs. Am. J. Physiol. 273 (Heart Circ. Physiol. 42): H1713–H1718, 1997.—The role of band aadrenoceptors in the total vascular capacitance responses to changing pressure in vascularly isolated carotid sinuses of anesthetized and atropinized dogs was investigated. A change in vascular capacitance was determined by measuring the shift of blood in and out of a reservoir that was connected to the aorta and maintained at a constant pressure. Changes in carotid sinus pressure from 135 to 57 mmHg and back to 137 mmHg resulted in a rapid vascular capacitance response of ,30 ml in the absence of adrenoceptor antagonists. Administration of a b2-adrenoceptor antagonist (ICI-118551) caused a significant enhancement of the capacitance responses to similar decreases and increases in carotid sinus pressure (,130%). Administration of a b1-adrenoceptor antagonist (CGP-20712A) did not cause any further enhancement of the responses. However, an a-blocker (phentolamine) reduced the responses by 75%. The results suggest that in the presence of a b2-adrenoceptor antagonist vascular capacitance responses to loading and unloading of baroreceptors are greatly enhanced and that patients suffering from orthostatic syncope may benefit from this kind of drug.