Microdevices for Isolating Single Axons for the Study of Axonal Transport in Dopaminergic Neurons
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منابع مشابه
Mechanisms of Observed Neuroprotection of Dopaminergic Neurons in Wallerian Degeneration Slow (WldS) Mice
An emerging hypothesis in Parkinson's disease (PD) is that dopaminergic (DA) neurons degenerate through a " dying back " axonopathy wherein degeneration begins in the distal axon and progresses over time towards the cell body. Impaired axonal transport also appears to play an early, pivotal role in PD. Thus processes that delay axonal transport dysfunction and/or axonal degeneration might slow ...
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Background & Aims : Axonal transport is a vital process in nervous system that protects axons and nerve terminals through supplying proteins, lipids and mitochondria and clearing folded proteins to avoid toxicity. Recently it is reported that impairment of motor proteins involved in axonal transport-like dynactin is a common factor in several neurodegenerative disorders such as Amyotrophic ...
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Background and purpose: Lesion on neural fiber is a phenomenon which can lead to cell death of the relevant functional neurons through a retrograde degeneration. Ïn order to show the probable effect of existing trophic factors present in immature brain (fetus) in maintaining and existence of mature motor neurons, this study was conducted experimentally on animals. Materials and Methods: Ïn...
متن کاملEarly Degeneration of Both Dopaminergic and Serotonergic Axons – A Common Mechanism in Parkinson’s Disease
Motor symptoms in Parkinson's disease (PD) are tightly linked to the degeneration of substantia nigra dopaminergic neurons and their projections into the striatum. Moreover, a broad range of non-motor symptoms like anxiety and depression frequently occur in PD, most likely related to the loss of serotonergic neurons and their projections into corresponding target regions. Strikingly, nigral dop...
متن کاملProtein translocation into dendrites: implication of glia-derived angiotensins in noradrenergic brainstem neurons
Noradrenaline (NA) released by dendrites of locus coeruleus (LC) neurons controls LC neuron activity, and hence, NA released from noradrenergic fibers in terminal fields. NA synthesis is dependent on tyrosine hydroxylase (TH), whose dendritic presence is controlled precisely in LC neurons during postnatal development. However, the mechanisms controlling specifically dendritic sorting of TH with...
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تاریخ انتشار 2016