TRANSLATIONAL PHYSIOLOGY Aspirin resistance with genetic dyslipidemia: contribution of vascular thromboxane generation
نویسندگان
چکیده
Jefferson C. Frisbee, Adam G. Goodwill, Phoebe A. Stapleton, Stephanie J. Frisbee, and Alexandre C. d’Audiffret Department of Physiology and Pharmacology, Division of Exercise Physiology, Department of Community Medicine, Division of Vascular and Endovascular Surgery, and the Center for Cardiovascular and Respiratory Sciences, West Virginia University Health Sciences Center, Morgantown, West Virginia
منابع مشابه
Aspirin resistance with genetic dyslipidemia: contribution of vascular thromboxane generation.
One clinical intervention against the negative outcomes associated with atherothrombotic vascular disease (AVD) is low-dose, chronic aspirin therapy. However, epidemiological studies suggest that recurrence of adverse vascular events with aspirin therapy is growing and associated with therapy duration. The contributors to this outcome are unclear and include poor patient compliance and aspirin-...
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Background: The rate of cardiovascular diseases in developing countries is approximately 60% and it is still has an increasing trend. The clinical effectiveness of aspirin in preventing cardiovascular events has been well proven. Although aspirin is an effective and inexpensive drug, its consumption is not equally beneficial for all patients. Many factors can be affective on the efficacy of ant...
متن کاملEffect of Glucose or Fat Challenge on Aspirin Resistance in Diabetes
Aspirin has lower antiplatelet activity in diabetic patients. Our aim is to study the roles of acute hyperglycemia and hyperlipidemia on aspirin function in diabetic subjects with and without cardiovascular disease. Using urine thromboxane (pg/mg creatinine) and VerifyNow (Aspirin Resistance Measures-ARU), we investigated diabetic subjects during a 2-hour glucose challenge (n = 49) or a 4-hour ...
متن کاملAspirin resistance.
To the Editor: Aspirin resistance is a poorly defined term and could involve the clinical inability of aspirin to protect individuals from arterial thrombotic events or laboratory methods indicating the failure of aspirin to inhibit platelet activity, mainly platelet aggregation. Indeed, resistance to aspirin may be associated with an increase of arterial thrombotic events in spite of chronic a...
متن کاملAspirin Resistance
To the Editor: Aspirin resistance is a poorly defined term and could involve the clinical inability of aspirin to protect individuals from arterial thrombotic events or laboratory methods indicating the failure of aspirin to inhibit platelet activity, mainly platelet aggregation. Indeed, resistance to aspirin may be associated with an increase of arterial thrombotic events in spite of chronic a...
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تاریخ انتشار 2010