TRANSLATIONAL PHYSIOLOGY Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathways
نویسندگان
چکیده
Raja-Elie E. Abdulnour, Xinqi Peng, Jay H. Finigan, Eugenia J. Han, Emile J. Hasan, Konstantin G. Birukov, Sekhar P. Reddy, James E. Watkins III, Usamah S. Kayyali, Joe G. N. Garcia, Rubin M. Tuder, and Paul M. Hassoun Division of Pulmonary and Critical Care Medicine, Department of Medicine, Department of Environmental Health Sciences, Bloomberg School of Public Health, and Division of Cardiopulmonary Pathology and Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and Pulmonary and Critical Care Division, Tupper Research Institute, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts
منابع مشابه
Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathways.
Xanthine oxidoreductase (XOR) plays a prominent role in acute lung injury because of its ability to generate reactive oxygen species. We investigated the role of XOR in ventilator-induced lung injury (VILI). Male C57BL/6J mice were assigned to spontaneous ventilation (sham) or mechanical ventilation (MV) with low (7 ml/kg) and high tidal volume (20 ml/kg) for 2 h after which lung XOR activity a...
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Signaling via p38 MAP kinase has been implicated in the mechanotransduction associated with mechanical stress and ventilator-induced lung injury (VILI). However, the critical downstream mediators of alveolar injury remain incompletely defined. We provide evidence that high-tidal volume mechanical ventilation (HVt MV) rapidly activates caspases within the lung, resulting in increased alveolar ce...
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Increased serum uric acid is known to be a major risk related to the development of several oxidative stress diseases. The aim of this study was to investigate the effect of parsley, quercetin and kaempferol on serum uric acid levels, liver xanthine oxidoreductase activity and two non-invasive biomarkers of oxidative stress (total antioxidant capacity and malondialdehyde concentration) in norma...
متن کاملEffects of Parsley (Petroselinum crispum) and its Flavonol Constituents, Kaempferol and Quercetin, on Serum Uric Acid Levels, Biomarkers of Oxidative Stress and Liver Xanthine Oxidoreductase Aactivity in Oxonate-Induced Hyperuricemic Rats
Increased serum uric acid is known to be a major risk related to the development of several oxidative stress diseases. The aim of this study was to investigate the effect of parsley, quercetin and kaempferol on serum uric acid levels, liver xanthine oxidoreductase activity and two non-invasive biomarkers of oxidative stress (total antioxidant capacity and malondialdehyde concentration) in norma...
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تاریخ انتشار 2006