Hypersensitivity of NHEJ Mutants to VP-16 and ICRF-193: Implications for the Repair of Topoisomerase II-mediated DNA Damage
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چکیده
Abbreviations: DSB, double-strand break; ES, embryonic stem; HR, homologous recombination; ICRF-193, meso-2,3-bis(2,6-dioxopiperazin-4-yl)butane; m-AMSA, 4'-(9-acridinylamino)methanesulfon-m-aniside; NHEJ, nonhomologous DNA endjoining; topo, DNA topoisomerase; TOP2α, the gene encoding topo IIα; VM-26, 4'demethylepipodophyllotoxin thenylidene-β-D-glucoside (teniposide); VP-16, demethylepipodophyllotoxin ethylidene-β-D-glucoside (etoposide).
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تاریخ انتشار 2003