Factor H Binding to PspC of Streptococcus pneumoniae Increases Adherence to Human 1 Cells
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چکیده
Factor H Binding to PspC of Streptococcus pneumoniae Increases Adherence to Human 1 Cells Lines In Vitro and Enhances Invasion of Mouse Lungs In Vivo. 2 Running title: Complement FH enhances pneumococcal adherence. 3 4 Lisa R. Quin 1 , Chinwendu Onwubiko 1 , Quincy C. Moore 1 , Megumi Fujioka Mills 1 , Larry S. 5 McDaniel 123* , and Stephanie Carmicle 1† 6 Departments of Microbiology 1 , Surgery 2 , and Medicine 3 , The University of Mississippi 7 Medical Center, Jackson, MS 39216. 8 *Corresponding author: 9 Larry S. McDaniel 10 Department of Microbiology 11 University of Mississippi Medical Center 12 2500 North State Street 13 Jackson, MS 39216 14 Phone: 601-984-6880 15 Fax: 601-984-1708 16 E-mail: [email protected] 17 18
منابع مشابه
Factor H binding to PspC of Streptococcus pneumoniae increases adherence to human cell lines in vitro and enhances invasion of mouse lungs in vivo.
Pneumococcal surface protein C (PspC) binds to both human secretory immunoglobulin A (sIgA) and complement factor H (FH). FH, a regulator of the alternative pathway of complement, can also mediate adherence of different host cells. Since PspC contributes to adherence and invasion of host cells, we hypothesized that the interaction of PspC with FH may also mediate adherence of pneumococci to hum...
متن کاملThe host immune regulator factor H interacts via two contact sites with the PspC protein of Streptococcus pneumoniae and mediates adhesion to host epithelial cells.
Pneumococcal surface protein C (PspC) of Streptococcus pneumoniae is a key virulence factor that mediates adhesion to host cells and immune evasion of the host complement. PspC binds the host immune and complement regulator factor H, which is composed of 20 short consensus repeats (SCR). This interaction contributes to pneumococcal virulence. In this study, we identified within the factor H pro...
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Streptococcus pneumoniae, also known as the pneumococcus, contains several surface proteins that along with the polysaccharide capsule function in antiphagocytic activities and evasion of the host immune system. These pneumococcal proteins interact with the host immune system in various ways and possess a wide range of biological activities that suggests that they may be involved at different s...
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BACKGROUND & OBJECTIVES Streptococcus pneumoniae has acquired virulence factors such as the polysaccharide capsule and various surface proteins, which prevent opsonization mediated by the complement system. PspC is one of the multi-functional pneumococcal surface proteins capable of eliciting an antibody response in mice. Our study further explores the role of pneumococcal surface proteins in r...
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تاریخ انتشار 2007