Toward a Genetic Understanding of Glaucoma-Breakthroughs and Challenges from Studies of Exfoliation Glaucoma.
نویسندگان
چکیده
منابع مشابه
Glutathione s-transferase M1 and T1 genetic polymorphisms in Iranian patients with glaucoma
Objective(s):Glaucoma is the second leading cause of blindness and it is related to oxidative stress based on numerous studies. Glutathione S-transferases (GSTs) are members of multigenic family, which have important role in cells as an antioxidant. In the present study, we examined the polymorphism of GSTT1 and GSTM1 deletion genotypes (T0M1, T1M0, and T0M0) in 100 Glaucoma patients (41with pr...
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PURPOSE The aim of the present study was to analyze the role of the two primary open angle glaucoma (POAG) genes, trabecular meshwork-induced glucocorticoid response (TIGR/MYOC) and optineurin (OPTN), in Finnish glaucoma families originating from southern coast of Finland. METHODS In total, 136 patients were examined to determine their ophthalmological status. Genealogical studies were perfor...
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95 The clinical entity collectively known as glaucoma is a very specific optic neuropathy that affects individuals with various degrees of ocular complications and even with greater degrees of genetic heterogeneity.[1,2] Although the very first genetic contribution to this group of eye disorders was described over 50 years ago,[3] it took another 30 years before the first molecular studies of t...
متن کاملAnimal models of exfoliation syndrome, now and future.
At present, no animal models fully embody exfoliation syndrome or exfoliation glaucoma. Both genetic and environmental factors appear critical for disease manifestation, and both must be considered when generating animal models. Because mice provide a powerful mammalian platform for modeling complex disease, this paper focuses on mouse models of exfoliation syndrome and exfoliation glaucoma.
متن کاملبررسی رابطه ی بین گلوکوم و کم شنوایی حسی عصبی
Introduction: Glaucoma is one of the leading causes of blindness throughout the world. Some studies have suggested a relationship between glaucoma and sensorineural hearing loss, while others have found no evidence of an association. We performed a study to determine whether there is a significant difference in hearing of patients with glaucoma and a match control population. Methods: In this...
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عنوان ژورنال:
- US ophthalmic review
دوره 4 1 شماره
صفحات -
تاریخ انتشار 2011