naffected Family Members and Schizophrenia Patients hare Brain Structure Patterns: A High-Dimensional attern Classification Study

ackground: A number of studies have provided evidence for genetic modulation of brain structure in unaffected family members (FM) of chizophrenia patients using conventional volumetric analysis. High-dimensional pattern classification methods have been reported to ave the capacity to determine subtle and spatially complex structural patterns that distinguish schizophrenia patients from healthy control ubjects using standard magnetic resonance imaging. This study investigates whether such endophenotypic patterns are found in FM via imilar image analysis approaches.