Chemical modification of steffimycin B.
نویسندگان
چکیده
Fifteen 3-substituted analogues of steffimycin B (1) have been synthesized and their activity against P388 murine leukemia has been determined. Three of these were substantially more active than the parent compound.
منابع مشابه
Steffimycin C, a new member of the steffimycin anthracyclines. Isolation and structural characterization.
Mother liquors from steffimycin B crystallizations have been processed to yield steffimycin C, a new member of the steffimycin family of anthracyclines. It has been identified, using spectroscopic methods, as 10-deoxysteffimycin B. Steffimycin C has antibacterial activity only against Streptococcus pneumoniae. Whether steffimycin C is a precursor of steffimycin B or a metabolic reduction produc...
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Steffimycin B, an anthracycline, has been isolated from cultures of Streptomyces elgreteus by solvent extraction and purified by silica gel chromatography. NM.R and mass spectroscopy indicate the presence of a methoxyl group in the sugar moiety of steffimycin B not found in steffimycin, a related antibiotic. Steffimycin B is not active against bacteria in experimentally infected animals, but ha...
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It has been shown that steffimycin (1) and steffmycin B (2) are reduced at the C-10 carbonyl by Actinoplanes utahensis, UC-5885 and Chaetomium sp., UC-4634, respectively. Using cell-free extracts of the latter organism, the optimum conversion time, pH, and enzyme concentration have been determined for the conversion of 2 to 4. The biochemical conversion of 2 has been found to be TPNH linked.
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متن کاملIsolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.
The biosynthetic gene cluster for the aromatic polyketide steffimycin of the anthracycline family has been cloned and characterized from "Streptomyces steffisburgensis" NRRL 3193. Sequence analysis of a 42.8-kbp DNA region revealed the presence of 36 open reading frames (ORFs) (one of them incomplete), 24 of which, spanning 26.5 kb, are probably involved in steffimycin biosynthesis. They code f...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 41 3 شماره
صفحات -
تاریخ انتشار 1988