Total synthesis of paracaseolide A.
نویسندگان
چکیده
The total synthesis of paracaseolide A, a valuable cell-cycle progression inhibitor, was accomplished in 8 steps from known compounds, with 6.6% overall yield. The synthetic strategy creates strong potential for diversification.
منابع مشابه
First total synthesis of paracaseolide A.
The first total synthesis of the paracaseolide A, a very unusual tetraquinane oxa-cage bislactone recently isolated from the mangrove Sonneratia paracaseolaris, has been achieved. The final step and culmination of the eight-step synthetic sequence is a [4 + 2] dimerization of a 4-hydroxybutenolide, generated by singlet oxygen-mediated oxidation of a furan precursor.
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عنوان ژورنال:
- Organic letters
دوره 15 3 شماره
صفحات -
تاریخ انتشار 2013