Proline-based reduced dipeptides as recyclable and highly enantioselective organocatalysts for asymmetric Michael addition.
نویسندگان
چکیده
A series of novel proline-based reduced dipeptides was developed and evaluated for a direct Michael addition of ketones and aldehydes to nitroalkenes. Excellent yields (up to 95%), diastereoselectivities (up to 98% dr) and enantioselectivities (up to 98% ee) were achieved in the presence of 5 mol% catalyst without any additional additives at room temperature.
منابع مشابه
Asymmetric Michael Addition Organocatalyzed by α,β-Dipeptides under Solvent-Free Reaction Conditions.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 9 19 شماره
صفحات -
تاریخ انتشار 2011