Can oxygen anosmia extend lifespan?
نویسندگان
چکیده
منابع مشابه
Biology of Ageing and Role of Dietary Antioxidants
Interest in relationship between diet and ageing is growing. Research has shown that dietary calorie restriction and some antioxidants extend lifespan in various ageing models. On the one hand, oxygen is essential to aerobic organisms because it is a final electron acceptor in mitochondria. On the other hand, oxygen is harmful because it can continuously generate reactive oxygen species (ROS), ...
متن کاملAging: The Blurry Line between Life and Death
Although historically reactive oxygen species have been implicated as a potential cause of ageing, recent evidence suggests that a modest increase in oxidants can actually extend lifespan. A new study suggests that, in Caenorhabditis elegans, reactive oxygen species regulate longevity through a pathway classically linked to apoptosis.
متن کاملForever young? Exploring the link between rapamycin, longevity and cancer
4296 Cell Cycle Volume 11 issue 23 There are a very few drug candidates that either extend lifespan or prevent a broad spectrum of age-related diseases. Of the few drug candidates that have exhibited preclinical success, rapamycin is the best characterized and perhaps shows the most promise for use in a clinical setting. Rapamycin inhibits the mTOR pathway, which integrates signals about nutrie...
متن کاملThe bright side of reactive oxygen species: lifespan extension without cellular demise.
Oxidative stress and the generation of reactive oxygen species (ROS) can lead to mitochondrial dysfunction, DNA damage, protein misfolding, programmed cell death with apoptosis and autophagy, and the promotion of aging -dependent processes. Mitochondria control the processing of redox energy that yields adenosine triphosphate (ATP) through the oxidation of glucose, pyruvate, and nicotinamide ad...
متن کاملRapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance
Rapamycin extends lifespan in mice, but can have a number of undesirable effects that may ultimately limit its utility in humans. The canonical target of rapamycin, and the one thought to account for its effects on lifespan, is the mammalian/mechanistic target of rapamycin, complex 1 (mTORC1). We have previously shown that at least some of the detrimental side effects of rapamycin are due to "o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 9 شماره
صفحات -
تاریخ انتشار 2017