Interrelationships between folic acid and cobalamin in the synthesis of methionine by extracts of Escherichia coli.

نویسندگان

  • R L KISLIUK
  • D D WOODS
چکیده

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Two enzymic mechanisms for the methylation of homocysteine by extracts of Escherichia coli.

Earlier work in this Laboratory has established conditions for the formation of methionine, from homocysteine plus serine or formaldehyde, by soluble enzyme systems extracted from Eseherichia coli. A cofactor of the folic acid group* is essential, and with E. coli PA 15 an extract of the heated organisms, H4PtG3 and its N5and N'0-formyl derivatives are all effective. H4PtG inhibits competitivel...

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عنوان ژورنال:
  • The Biochemical journal

دوره 75  شماره 

صفحات  -

تاریخ انتشار 1960