SAR and identification of 2-(quinolin-4-yloxy)acetamides as Mycobacterium tuberculosis cytochrome bc 1 inhibitors† †The authors declare no competing interests. ‡ ‡Electronic supplementary information (ESI) available: Materials and methods, and characterisation of compounds 10a–f, 11a–x and 5, 9, 12a–12aa. See DOI: 10.1039/c6md00236f Click here for additional data file.

SAR and identification of 2-(quinolin-4-yloxy)acetamides as Mycobacterium tuberculosis cytochrome bc1 inhibitors.

A previous phenotypic screen by GSK identified 2-(quinolin-4-yloxy)acetamides as potent growth inhibitors of Mycobacterium tuberculosis (Mtb). We report the results of a preliminary structure-activity relationship (SAR) study of the compound class which has yielded more potent inhibitors. An Mtb cytochrome bd oxidase deletion mutant (cydKO) was found to be hypersensitive to most members of the ...

From linked open data to molecular interaction: studying selectivity trends for ligands of the human serotonin and dopamine transporter† †The authors declare no competing interests. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c6md00207b Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file.

Enantioselective Narasaka–Heck cyclizations: synthesis of tetrasubstituted nitrogen-bearing stereocenters† †Electronic supplementary information (ESI) available: Experimental procedures and characterisation data for all compounds are provided. CCDC 1438659 and 1438660. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc04466b Click here for additional data file. Click here for additional data file.

School of Chemistry, University of Bristol, B bris.ac.uk AstraZeneca, Alderley Park, Maccleseld, C AstraZeneca, Pepparedsleden 1, Mölndal, 4 † Electronic supplementary information ( and characterisation data for all compou 1438660. For ESI and crystallographic dat DOI: 10.1039/c6sc04466b ‡ These authors contributed equally. § Author to whom correspondence shou structures of 3b and Pd[(Sa,S)-L-...

Nonomuraea sp. ATCC 55076 harbours the largest actinomycete chromosome to date and the kistamicin biosynthetic gene cluster† †The authors declare no competing interests. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c6md00637j Click here for additional data file.

Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase† †The authors declare no competing interests. ‡ ‡Electronic supplementary information (ESI) available: Synthesis details and structural characterization of compounds, X-ray data collection and statistics, supplementary Fig. S1–S6. See DOI: 10.1039/c6md00531d Click here for additional data file.

a Department of Chemistry, Imperial College London, London SW7 2AZ, United Kingdom b Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5DD, United Kingdom *E-mail: [email protected] *E-mail: [email protected] †Electronic Supplementary Information (ESI) available: Synthesis details and structural characterization of compounds, X-ray data coll...