The effect of autologous serum on lymphocyte response to human leukemia cells.

The normal lymphocytes of 11 of 18 paexpectation of demonstrating a “blocktients with acute leukemia in remission ing” effect of the former and no effect or showed a positive blastogenic response perhaps even facilitation with the latter. in vitro to autologous leukemia cells. The However, this was not the case, and no effect of autologous serum on this response consistent differences in blastogenesis in was studied to determine if there were the presence of the two sera were seen. factors which might abrogate or “block” In addition, during the period of observathis response. Serum obtained at diagnosis tion, there was little correlation between (i.e., during a tumor-bearing period) was the presence or absence of in vitro recompared with remission serum with the sponse to autologous tumor and prognosis.