Abstract 69: Stem Cells Harvested from Bone Marrow and Adipose Tissue Demonstrate Equivalent Healing but Through Different Mechanisms in a Murine Model of Irradiated Mandibular Fracture Healing
نویسندگان
چکیده
METHODS: Immunocompromised nude-mice underwent external beam irradiation of the scalp. Five weeks later, mice either received seven deferoxamine treatments (1mg in 100ul) or saline subcutaneously to the irradiated area every other day. Laser Doppler analysis (LDA) was recorded prior to irradiation, following irradiation, and 24 hours following each treatment. Human fat grafts were then injected in the subcutaneous plane of the scalp and volume retention measured by CT scan over 8 weeks. Finally, skin and fat samples were evaluated histologically for vasculature, dermal thickness, and fat graft quality.
منابع مشابه
Abstract 48. Stem Cells Harvested from Bone Marrow and Adipose Tissue Demonstrate Differential Healing Mechanisms and Union Rates in a Murine Model of Irradiated Mandibular Fracture Repair
METHODS: Custom 3DBC scaffolds were either coated with collagen (control) or coated with collagen and immersed in 100 μM dipyridamole (DIPY). Sheep (n=5) were subjected to 4 trephine-induced (12 mm diameter) calvarial defects with immediate scaffold placement via two separate operations: anteriorly (control) and posteriorly (DIPY) on the right (3 weeks healing) and left (6 weeks healing) sides ...
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Purpose: Effects of TGF-b and b-FGF on the Potential of Peripheral Blood-Borne Stem Cells and Bone Marrow-Derived Stem Cells In Wound Healing in a Murine Model.Materials and Methods: Peripheral blood mesenchymal stem cells (PBMSCs) and bone marrow stem cells (BMSCs) cultured in media with transforming growth factor-beta (TGF-b) and basic fibroblast growth factor (b-FGF). Stem cells labeled with...
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Objective: In this study, the bone regeneration ability of polyacrylamide hydrogel and nanohydroxyapatite scaffolds (PAAH/NHA) and stem cells derived from adipose tissue (ADSCs) in the healing of critical sized bone defects in rabbit radius were assessed. Animals and procedures: 12 New Zealand white male rabbits were divided into 3 groups. The rabbits were anesthetized and 15 mm bone def...
متن کاملReconstructionof Human Mandibular Continuity Defects with Allogenic Scaffold and Autologousmarrow Mesenchymal Stem Cells
Background Mandibular continuity defects occur after tumor resection, maxillofacial injury, or osteomyelitis. Despite the current availability of a plethora of treatment modalities, bone substitutes, and various clinical adjuncts, an exact reconstructive recapitulation of large bony defects continues to be beyond reach. In this clinical pilot study, we report a novel method for reconstruction ...
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عنوان ژورنال:
دوره 5 شماره
صفحات -
تاریخ انتشار 2017