Statin-induced cholestatic hepatitis: confirmed on rechallenge.

Address correspondence to: Dr Charles Berkelhammer, 9921 Southwest Highway, Oak Lawn, IL 60453; Tel: 708-499-5678; Fax: 708-499-5685; E-mail: [email protected] Although statins have been associated with an increase in serum aminotransferase levels,1,2 these elevations may resolve spontaneously in 70% of patients despite continued therapy and may not be associated with significant liver injury.3 Statin-induced idiosyncratic liver injury that is severe enough to cause morbidity and mortality is rare, with only a few of these cases confirmed by rechallenge.4 We describe a patient with statin-induced symptomatic cholestatic hepatitis that was confirmed on rechallenge.