Antibiotic selectivity for prokaryotic vs. eukaryotic decoding sites.
نویسندگان
چکیده
A FRET assembly reports antibiotic affinities to two different RNA targets. A binder was labeled with a fluorophore that acts both as an acceptor for the emissive nucleoside on the bacterial A-site and a donor fluorophore for the terminally-labeled human A-site. Unlabeled drugs were used to dissociate the labeled antibiotic.
منابع مشابه
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عنوان ژورنال:
- Chemical communications
دوره 46 30 شماره
صفحات -
تاریخ انتشار 2010