The partial purification of thiamine triphosphatase from rat brain.
نویسندگان
چکیده
In continuing studies in this laboratory on the role of thiamine in nervous tissue we have recently accumulated some evidence to suggest that the neurophysiologically active form of the vitamin may be thiamine triphosphate (TTP) as opposed to the coenzyme form, thiamine pyrophosphate (thiamine-PP) (l-3). Since a specific enzyme exists in brain which catalyzes the hydrolysis of thiamine-PP (4), we thought it likely that a corresponding phosphatase would also exist for TTP. This paper concerns the partial purification of thiamine triphosphatase and some properties of the enzyme.
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عنوان ژورنال:
- The Journal of biological chemistry
دوره 247 7 شماره
صفحات -
تاریخ انتشار 1972