Quantitative time-lapse imaging (QTLI)-based analysis of drug-drug interaction mediated by hepatobiliary transporter, multidrug resistance associated protein 2, in sandwich-cultured rat hepatocytes
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چکیده
Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192 (T. N., Y. S., Y. F., H. F., Y. S., I. T.) and Department of Membrane Transport and Pharmacokinetics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamasaki, Noda, Chiba 278-8510 (Y. S., K. Y., Y. S., I. T.), Japan DMD Fast Forward. Published on March 17, 2011 as doi:10.1124/dmd.111.038059
منابع مشابه
Quantitative time-lapse imaging-based analysis of drug-drug interaction mediated by hepatobiliary transporter, multidrug resistance-associated protein 2, in sandwich-cultured rat hepatocytes.
There is increasing interest in developing efficient screening platforms to predict drug-induced liver injury. Therefore, we explored a microscope-based analysis to quantitatively evaluate interaction of drugs with multidrug resistance-associated protein 2 (MRP2), essential for hepatic excretion of drugs in sandwich-cultured rat hepatocytes (SCRHs), using 5 (and 6)-carboxy-2',7'-dichlorofluores...
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تاریخ انتشار 2011