DIARRHEA OUTBREAK IN PERNAMBUCO, BRAZIL, ASSOCIATED WITH A HEAT-STABLE CYTOTOXIC ENTEROTOXIN PRODUCED BY Aeromonas caviae.
نویسندگان
چکیده
In the present study enterotoxic and cytotoxic activities of twenty Aeromonas caviae strains were examined. They originated from fecal specimens of patients with acute diarrhea during an outbreak in Brazil in 2004. Culture supernatants of fourteen strains (70%) caused fluid accumulation in rabbit ileal intestinal loops and in suckling mice assays, and also showed a cytotoxic activity in Vero and Caco-2 cells. The enterotoxic and cytotoxic factors were heat-stable after culture supernatants treatment at 100 ºC. The results revealed that A. caviae strains produce a putative diarrheagenic virulence factor, a heat-stable cytotoxic enterotoxin that could be linked to the diarrhea outbreak that took place in Brazil.
منابع مشابه
[Aeromonas associated with an acute diarrhea outbreak in São Bento do Una, Pernambuco].
An acute diarrhea outbreak, with 2170 cases, was described during January to July, 2004, in São Bento do Una, Pernambuco. 582 stools were examined and an enteric pathogen was recovered in 25% (145 patients). Aeromonas species were the most frequent (114-19.5%) and the main isolates were Aeromonas caviae (57-9.8%), Aeromonas veronii biovar sobria (23-3.9%), Aeromonas veronii biovar veronii (15-2...
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عنوان ژورنال:
- Revista do Instituto de Medicina Tropical de Sao Paulo
دوره 57 4 شماره
صفحات -
تاریخ انتشار 2015