Mutational Site of the Gene Controlling Quantitative Thymine Requirement in Escherzchza

Implementation of HSE Requirement in architectural design and Constructions of Residential complexs

HSE management involves managing, controlling and handling all aspects of health, safety and the environment in the petroleum industry with the focus on major accident risk. In the field of residential and building construction ventures the workings met lots of practical hitches like procedure, responsibility, monitoring, evaluation housekeeping at Construction Sites and associated offices, per...

Mutational Screening in Exon 6 of the PSEN2 Gene in Iranian Patients with Late-Onset Alzheimer\'s Disease

Background and Aims: One of the most important genes involved in Alzheimer's disease (AD) is the presenilin2 (PSEN2) gene, which is one of the main constituents of the gamma-secretase complex. Mutations in this gene promote the formation of amyloid plaques resulting in AD. The study aimed to evaluate the mutation variant in exon 6 of the PSEN2 gene in patients with Late-Onset AD (LOAD). Due to ...

Mutational analysis of ARSB gene in mucopolysaccharidosis type VI: identification of three novel mutations in Iranian patients

Objective(s): Mucopolysaccharidosis VI (MPS VI) or Maroteaux-Lamy syndrome is a rare metabolic disorder, resulting from the deficient activity of the lysosomal enzyme arylsulfatase B (ARSB).  The enzymatic defect of ARSB leads to progressive lysosomal storage disorder and accumulation of glycosaminoglycan (GAG) dermatan sulfate (DS), which causes harmful effects on various organs and tissues an...

Separating substrate recognition from base hydrolysis in human thymine DNA glycosylase by mutational analysis.

Human thymine DNA glycosylase (TDG) was discovered as an enzyme that can initiate base excision repair at sites of 5-methylcytosine- or cytosine deamination in DNA by its ability to release thymine or uracil from G.T and G.U mismatches. Crystal structure analysis of an Escherichia coli homologue identified conserved amino acid residues that are critical for its substrate recognition/interaction...

Sharp kink of DNA at psoralen-cross-link site deduced from crystal structure of psoralen-thymine monoadduct.