Glycoprotein lIb - Illa Complex and Ca 2 Influx Into Stimulated Platelets
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چکیده
Changes in intracellular Ca2 concentrations (ICa2 ]j) in platelets stimulated with aggregating agents were measured with the fluorescent indicator dye quin 2. Ca2 influx, but not intracellular mobilization, in response to adenosine diphosphate (ADP). platelet aggregating factor (PAFacether). and sodium arachidonate was significantly inhibited by monoclonal antibodies against the glycoprotein (GP) llb-Illa complex; inhibition of thrombin-stimulated influx was inhibited to a lesser extent and reached statistical significance only at thrombin concentrations of 0.1 U/mI
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تاریخ انتشار 2005