Single-dose azithromycin for trachoma.
نویسندگان
چکیده
منابع مشابه
Operational comparison of single-dose azithromycin and topical tetracycline for trachoma.
PURPOSE World Health Organization guidelines for antibiotic treatment of trachoma currently include a 6-week course of tetracycline eye ointment twice daily or a single dose of oral azithromycin. Previous trials have shown similar efficacy of these two alternatives when administration of the ointment was carefully supervised. It is believed, however, that azithromycin may be a more effective tr...
متن کاملSingle-dose azithromycin prevents trichiasis recurrence following surgery: randomized trial in Ethiopia.
BACKGROUND Trichiasis recurrence following surgery is a serious problem for trachoma programs. OBJECTIVE To determine if postoperative treatment with azithromycin compared with topical tetracycline reduces recurrence up to 1 year, and if azithromycin treatment of household members provides additional benefit compared with treating only the surgical patient. DESIGN A randomized, single-maske...
متن کاملShort-Term Malaria Reduction by Single-Dose Azithromycin during Mass Drug Administration for Trachoma, Tanzania
Single-dose mass drug administration of azithromycin (AZT) is underway to eliminate trachoma worldwide. Studies in Ethiopia showed a reduction in all-cause childhood deaths after administration. To examine the effect of single-dose AZ MDA on prevalent malaria infections in a large prospective cohort of children and parents in Dodoma Province, Tanzania, we quantified the temporal prevalence of m...
متن کاملAlterations in the conjunctival bacterial flora following a single dose of azithromycin in a trachoma endemic area.
BACKGROUND/AIMS The World Health Organisation has recommended repeated mass treatment of children in trachoma endemic areas with oral azithromycin. While chlamydia, the causative agent of trachoma, remains universally sensitive to azithromycin, there is concern that large scale programmes may alter the bacterial flora and induce resistance in streptococcal species. In this study the effect of a...
متن کاملMass treatment with single-dose azithromycin for trachoma.
BACKGROUND Trachoma, caused by repeated ocular infection with Chlamydia trachomatis, is an important cause of blindness. Current recommended dosing intervals for mass azithromycin treatment for trachoma are based on a mathematical model. METHODS We collected conjunctival swabs for quantitative polymerase-chain-reaction assay of C. trachomatis before and 2, 6, 12, 18, and 24 months after mass ...
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عنوان ژورنال:
- The New England journal of medicine
دوره 352 4 شماره
صفحات -
تاریخ انتشار 2005