Cognitive Subscore Trajectory Prediction in Alzheimer's Disease

Accurate diagnosis of Alzheimer’s Disease (AD) entails clinical evaluation of multiple cognition metrics and biomarkers. Metrics such as the Alzheimer’s Disease Assessment Scale-Cognitive test (ADAS-cog) [7] comprise multiple subscores that quantify different aspects of a patient’s cognitive state such as learning, memory, and language production/comprehension. Although computeraided diagnostic techniques for classification of a patient’s current disease state exist [4], they provide little insight into the relationship between changes in brain structure and different aspects of a patient’s cognitive state that occur over time in AD.