Fredericamycin A, a new antitumor antibiotic. II. Biological properties.

نویسندگان

  • D J Warnick-Pickle
  • K M Byrne
  • R C Pandey
  • R J White
چکیده

Fredericamycin A is a novel antibiotic produced by a soil isolate of Streptomyces griseus (FCRC-48). In vitro, fredericamycin A exhibits antibacterial, antifungal, and cytotoxic activities. In vivo, fredericamycin A exhibits very good antitumor activity against P388 mouse leukemia as well as the CD8F mammary tumor and marginal activity against B16 melanoma. Fredericamycin A failed to demonstrate any interaction with DNA and inhibited protein and RNA synthesis preferentially to DNA synthesis in Bacillus subtilis and P388 cells.

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 34 11  شماره 

صفحات  -

تاریخ انتشار 1981