EFFECT OF FONDAPARINUX ON PLATELET ACTIVATION IN THE PRESENCE OF HEPARIN-DEPENDENT ANTIBODIES. A BLINDED COMPARATIVE MULTICENTER STUDY WITH UNFRACTIONATED HEPARIN. Short title: Fondaparinux and heparin-induced thrombocytopenia
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چکیده
1: Sanofi~Synthélabo Recherche, Toulouse, France 2: Department of Medicine, The St George Hospital, Kogarah, Australia 3: Department of Immunology and Transfusion Medicine, Ernst-Moritz-Arndt-University, Greifswald, Germany 4: Service d’Hématologie-Hémostase, Hôpital Trousseau, Tours, France 5: Platelet Immunology Laboratory, McMaster University, Hamilton, Ontario, Canada 6: NV Organon, Oss, The Netherlands
منابع مشابه
Incidence of bleeding symptoms in 100 patients with inherited afibrinogenemia or hypofibrinogenemia.
arin-induced thrombocytopenia. Curr Hematol Rep 2003; 2: 148–57. 4 Shibata S, Harpel PC, Gharavi A, Rand J, Filit H. Autoantibodies to heparin from patients with antiphospholipid antibody syndrome inhibit formation of antithrombin III-thrombin complexes. Blood 1994; 83: 2532–40. 5 Martinuzzo ME, Forastierio RR, Adamczuk Y, Pombo G, Carreras LO. Antiplatelet factor 4–heparin antibodies in patien...
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Heparin-induced thrombocytopenia (HIT) is caused by platelet-activating IgG antibodies that recognize platelet factor 4 (PF4) bound to heparin. Immunogenicity of heparins differs in that unfractionated heparin (UFH) induces more anti-PF4/heparin antibodies than low-molecular-weight heparin (LMWH) and UFH also causes more HIT. Fondaparinux, a synthetic anticoagulant modeled after the antithrombi...
متن کاملUltralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia.
Heparin-induced thrombocytopenia and thrombosis (HITT) is a severe complication of heparin therapy caused by antibodies to complexes between unfractionated heparin (UFH) and platelet factor 4 (PF4) that form over a narrow molar range of reactants and initiate antibody-induced platelet activation. We observed that UFH and tetrameric PF4 formed ultralarge (> 670 kDa) complexes (ULCs) only over a ...
متن کاملHEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia
Heparin-induced thrombocytopenia and thrombosis (HITT) is a severe complication of heparin therapy caused by antibodies to complexes between unfractionated heparin (UFH) and platelet factor 4 (PF4) that form over a narrow molar range of reactants and initiate antibody-induced platelet activation. We observed that UFH and tetrameric PF4 formed ultralarge (> 670 kDa) complexes (ULCs) only over a ...
متن کاملThe serological profile of fondaparinux-associated heparin-induced thrombocytopenia syndrome.
doi:10.1160/TH12-03-0201 Thromb Haemost 2012; 108: 394–396 Dear Sirs, Heparin-induced thrombocytopenia (HIT) is a prothrombotic adverse drug effect caused by platelet-activating antibodies that recognise multimolecular complexes of platelet factor 4 (PF4) bound to heparin (1, 2). HIT is almost invariably triggered by proximate treatment with unfractionated heparin (UFH) or low-molecular-weight ...
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تاریخ انتشار 2004