C/EBP functionally and physically interacts with GABP to activate the human myeloid IgA Fc receptor (Fc R, CD89) gene promoter

C/EBP and Ets Protein Family Members Regulate the Human Myeloid IgA Fc Receptor (Fc R, CD89) Promoter

CD89: the human myeloid IgA Fc receptor.

CD89 (Fc alphaRI) is the human myeloid IgA Fc receptor expressed on cells, such as neutrophils, eosinophils and monocytes/macrophages. Cross-linking of CD89 on these cells, by IgA-opsonised particles (e.g. bacteria, viruses) or anti-CD89 monoclonal antibodies, can trigger various immunological effector functions which are generally protective but may also cause harm to the body. CD89 is a trans...

GABP cooperates with c-Myb and C/EBP to activate the neutrophil elastase promoter.

Neutrophil elastase (NE) is a serine protease that is transcriptionally regulated during early myeloid differentiation. The murine NE (mNE) promoter contains functionally important c-Myb, C/EBP, and ets binding sites. Deletion of the ets site reduced promoter activity by 90%. Although the ets transcription factor, PU.1, bound to this ets site, it only modestly activated the mNE promoter. Here, ...

Mediation and Modulation of Antibody Function

IgA plays a key role in immune defence of the mucosal surfaces. IgA can trigger elimination mechanisms against pathogens through the interaction of its Fc region with FcaRs (receptors specific for the Fc region of IgA) present on neutrophils, macrophages, monocytes and eosinophils. The human FcaR (CD89) shares homology with receptors specific for the Fc region of IgG (FcyRs) and IgE (FceRIs), b...

Human mesangial cells in culture and in kidney sections fail to express Fc alpha receptor (CD89).

The mechanism of deposition of IgA in the renal mesangium in primary IgA-nephropathy is poorly understood. It has been suggested that membrane receptors for IgA on mesangial cells (MC) of the kidney may be involved. To obtain more insight in the occurrence of the myeloid receptor for IgA (CD89) on MC, both in situ and in culture, rabbit and goat polyclonal antibodies and mouse monoclonal antibo...