Dengue: defining protective versus pathologic immunity.
نویسنده
چکیده
Dengue is an expanding public health problem, and an effective vaccine remains elusive. This review discusses how the significant influence of sequential infection with different dengue virus serotypes on the severity of disease can be viewed in terms of beneficial and detrimental effects of heterologous immunity. A more complete understanding of these effects is likely to be critical for predicting optimal vaccine-induced immune responses.
منابع مشابه
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عنوان ژورنال:
- The Journal of clinical investigation
دوره 113 7 شماره
صفحات -
تاریخ انتشار 2004