Humanizing mice for the identification of novel anticancer lipids targeting iNKT cells
نویسندگان
چکیده
The CD1d-dependent presentation of lipid antigens to natural killer T (NKT) cells is an integral part of the innate immune system. However, the development of anticancer therapies based on NKT-cell agonists has had limited success so far. Humanizing mice with respect to the CD1d/NKT antigen presentation system will provide a tool to identify novel lipids that exert antineoplastic functions by targeting NKT cells before the initiation of costly and lengthy clinical trials.
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2013