Beta-adrenergic induction of a cysteine-proteinase-inhibitor mRNA in rat salivary glands.
نویسندگان
چکیده
Transcripts encoding the cysteine-proteinase inhibitor rat cystatin S are induced in submandibular and parotid glands by the beta-adrenergic agonist isoproterenol (isoprenaline). High levels of cystatin S mRNA persist in glands of chronically treated animals for 6 days after discontinuation of the catecholamine, indicating a long half-life of the mRNA. Post-transcriptionally the size of the mRNA decreases, owing to a shortening of the poly(A) tail.
منابع مشابه
Cloning and sequencing of cDNA encoding a rat salivary cysteine proteinase inhibitor inducible by beta-adrenergic agonists.
The beta-adrenergic agonist isoproterenol induces a unique secretory protein (LM) in the salivary glands of developing and adult rats. In order to study the regulation of growth and gene expression by catecholamines, we have isolated and sequenced several cDNA clones encoding the LM protein. Each of the LM cDNA clones described identifies, by Northern blot analyses, a single mRNA species of app...
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عنوان ژورنال:
- The Biochemical journal
دوره 257 3 شماره
صفحات -
تاریخ انتشار 1989