Synthesis and cytotoxicity of a cobaltcarbonyl-alkyne enkephalin bioconjugate.
نویسندگان
چکیده
A solid-phase synthesized propargyl derivative of the neuropeptide leucine-enkephalin (Enk) reacts rapidly and quantitatively with Co(2)(CO)(8) to give the Co(2)(CO)(6)-alkyne labeled peptide , which is the first organometallic peptide bioconjugate to show significant toxicity against two different tumor cell lines.
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عنوان ژورنال:
- Chemical communications
دوره 2 شماره
صفحات -
تاریخ انتشار 2008