Genetically modified ruminal bacteria protect sheep from fluoroacetate poisoning.
نویسندگان
چکیده
Four strains of Butyrivibrio fibrisolvens, transformed with a gene encoding fluoroacetate dehalogenase, maintained a combined population of 10(6) to 10(7) cells ml-1 in the rumens of test sheep. Five inoculated sheep showed markedly reduced toxicological symptoms after fluoroacetate poisoning when behavioral, physiological, and histological effects were compared with those of five uninoculated control sheep.
منابع مشابه
Genetically modified rumen bacteria protect sheep from fluoroacetate poisoning
In two separate experiments, test sheep were inoculated with a mixture of four genetically modified strains of Butyrivibrio fibrisolvens, which attained a combined population level of 1 06-10’ cells per ml in each animal. The bacteria had been modified to express the enzyme fluoroacetate dehalogenase. Uninoculated sheep were used as controls. Experiment I included two Merino/ Border Leicester c...
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عنوان ژورنال:
- Applied and environmental microbiology
دوره 64 9 شماره
صفحات -
تاریخ انتشار 1998